

On the issue of the consequences of oil and petroleum product spills for human health: a literary review
EDN: CMHZJX
Abstract
The Kerch strait accident in December 2024 once again attracted the attention of not only experts in the field of eliminating the technical causes and consequences of technogenic accidents, but also scientists assessing the damage caused to nature and human health. The analysis of the information accumulated in the world practice concerning various aspects of this problem can contribute to a better understanding of its importance, and, therefore, be of interest for its constructive solution.
The aim of this review is to analyze the available information on the consequences of oil and petroleum product spill precedents in domestic and international practice, as well as scientific and research data that make it possible to assess and predict possible effects on human health. It is made in the following directions: l precedents of such accidents in domestic and international practice; characteristics of oil and petroleum products and their impact on environmental objects. l epidemiological studies of the consequences of oil and petroleum product spill accidents; l experimental and field studies of the physiological effects of influence on representatives of the animal world.
About the Authors
Elena V. EvstafevaRussian Federation
Kurchatova Str., 7, Sevastopol, 299015
Mukhina Str., 10/3, Yalta, 298603
Dmitry S. Kadochnikov
Russian Federation
Kurchatova Str., 7, Sevastopol, 299015
Olga Yu. Gritskevich
Russian Federation
Kurchatova Str., 7, Sevastopol, 299015
Irina A. Evstafeva
Russian Federation
Av., 4, Simferopol, 295007
References
1. Vorobyov Yu. L. Systemic accidents and disasters in the technosphere of Russia / Yu. L. Vorobyov, V. A. Akimov, Yu. I. Sokolov. M.: All- Russian Research Institute for Civil Defense and Emergencies EMERCOM of Russia. 2012. 308 p. ISBN 978-5–93970-075-7. EDN PIJBZL (In Russ.)]
2. Belobrov E. P., Ponomarenko A. N., Shafran L. M., Repetey V. D. Ecological and hygienic aspects of liquidation consequences of ships with dangerous goods onboard destruction in the Kerch strait // Current Problems of Transport Medicine. 2007;(4):9-18. (In Russ.)]
3. Johnston JE, Lim E, Roh H. Impact of upstream oil extraction and environmental public health: A review of the evidence. Sci Total Environ. 2019 Mar 20;657:187-199. https://doi.org/10.1016/j.scitotenv.2018.11.4834
4. Hook SE, et al. The Influence of Oil-in- Water Preparations on the Toxicity of Crude Oil to Marine Invertebrates and Fish Following Short- Term Pulse and Continuous Exposures/ Hook SE, Strzelecki J, Adams MS, Binet MT, McKnight K, Golding LA, Elsdon TS. // Environ Toxicol Chem. 2022 Oct;41(10):2580-2594. https://doi.org/10.1002/etc.5437
5. Orujev R. A., Jafarova R. E. The peculiarities of the toxic effect of petroleum hydrocarbons on the human organism // Vitebsk Medical Journal. 2017;16(4):8-15. (In Russ.) https://doi.org/10.22263/2312-4156.2017.4.8]
6. Van den Heuvel- Greve MJ, et al. Temperate Versus Arctic: Unraveling the Effects of Temperature on Oil Toxicity in Gammarids / Van den Heuvel-G reve MJ, Jonker MTO, Klaassen MA, Puts IC, Verbeeke G, Hoekema L, Foekema EM, Murk AJ. // Environ Toxicol Chem. 2024 Jul;43(7):1627-1637. https://doi.org/10.1002/etc.5897. Epub 2024 Jun 5.
7. Amoatey P. et al. Characterization and exposure assessment to urban air toxics across Middle Eastern and North African countries: a review / Amoatey P, Al- Mayahi A, Al- Harthy I, Al- Jabri K, Addi MN, Siddiqi SA, Sulaiman H, Al- Mamun A, Baawain MS.// Environ Monit Assess. 2021 Jul 28;193(8):529 https://doi.org/10.1007/s10661-021-09229-1. PMID: 34322756 Review.
8. Dettman HD, et al. Recommendations for the advancement of oilin-water media and source oil characterization in aquatic toxicity test studies / Dettman HD, Wade TL, French- McCay DP, Bejara- no AC, Hollebone BP, Faksness LG, Mirnaghi FS, Yang Z, Loughery J, Pretorius T, de Jourdan B. // Aquat Toxicol. 2023 Aug;261:106582. https://doi.org/10.1016/j.aquatox.2023
9. Laffon B, Pásaro E, Valdiglesias V. Effects of exposure to oil spills on human health: Updated review // J Toxicol Environ Health B Crit Rev. 2016;19(3-4):105-28. https://doi.org/10.1080/10937404.2016.1168730. Epub 2016 May 24
10. Huynh BQ et al. Public health impacts of an imminent Red Sea oil spill / Huynh BQ, Kwong LH, Kiang MV, Chin ET, Mohareb AM, Jumaan AO, Basu S, Geldsetzer P, Karaki FM, Rehkopf DH // Nat Sustain. 2021 Dec;4(12):1084-1091. https://doi.org/10.1038/s41893-021-00774-8)
11. Kenesariev U. I., Yerzhanova A. E., Kenessary D. U., Kenessary A. U. Trends of change in demographic indices of population in the area of oil and gas deposits of the republic of Kazakhstan // Hygiene and Sanitation. 2016;95(10):946-949. (In Russ.) https://doi.org/10.18821/0016-9900-2016-95-10-946-949]
12. Tussupkaliyev A. B., Sarsembayeva L. K., Abdrakhmanova A. A. Women’s health condition in the oil and gas areas of Aktobe region // Medical Journal of Western Kazakhstan. 2018;(1):10-14. (In Russ.)]
13. Ivanova M. K., Bakshaeva A. N., Kuznetsova E. P. et al. Features of women’s reproductive health and health of children living in areas of oil extraction // Health, Demography, Ecology of the Finno-U gric Peoples. 2018;(3):30-35. (In Russ.)]
14. Ginko I. V., Sushinskaya T. M., Rybina A. L. Assessment of the impact of factors of the working environment on the health of workers in oil refining based on the analysis of morbidity // Russian Journal of Occupational Health and Industrial Ecology. 2019;59(9):600-601. (In Russ.) https://doi.org/10.31089/1026-9428-2019-59-9–600-601]
15. Fowles JR, et al. Assessment of petroleum streams for thyroid toxicity / Fowles JR, Banton MI, Boogaard PJ, Ketelslegers HB, Rohde AM. // Toxicol Lett. 2016 Jul 8;254:52-62. https://doi.org/10.1016/j.toxlet.2016.05.001. Epub 2016 May 2. PMID: 27150732
16. Connellan SJ. Lung diseases associated with hydrocarbon exposure // Respir Med. 2017 May;126:46-51. https://doi.org/10.1016/j.rmed.2017.03.021. Epub 2017 Mar 23. PMID: 28427549 Free article. Review
17. Xiong Y, Zhou J, Xing Z, Du K. Cancer risk assessment for exposure to hazardous volatile organic compounds in Calgary, Canada // Chemosphere. 2021 Jun;272:129650. https://doi.org/10.1016/j.chemosphere.2021.129650. Epub 2021 Jan 14
18. Landwehr KR, et al. Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model / Landwehr KR, Hillas J, Mead-H unter R, Brooks P, King A, O’Leary RA, Kicic A, Mullins BJ, Larcombe AN; AusREC; and; WAERP. // J Hazard Mater. 2021 Oct 15;420:126637. https://doi.org/10.1016/j.jhazmat.2021.126637
19. Uski OJ, et al. The Toxic Effects of Petroleum Diesel, Biodiesel, and Renewable Diesel Exhaust Particles on Human Alveolar Epithelial Cells / Uski OJ, Rankin G, Wingfors H, Magnusson R, Boman C, Lindgren R, Muala A, Blomberg A, Bosson JA, Sandström T. // J Xenobiot. 2024 Oct 9;14(4): 1432-1449. https://doi.org/10.3390/jox14040080
20. Bakshayeva A. N., Tetelyutina F. K., Ivanova M. K. Reproductive health of women, its relationship with oil production factors (literature review) // Health, Demography, Ecology of the Finno-U gric Peoples. 2024;(2):83-89. (In Russ.)]
21. Muda I, et al. Associated health risk assessment due to exposure to BTEX compounds in fuel station workers / Muda I, Mohammadi MJ, Sepahvad A, Farhadi A, Fadhel Obaid R, Taherian M, Alali N, Chowdhury S, Farhadi M. // Rev Environ Health. 2023 Mar 14;39(3):435-446. https://doi.org/10.1515/reveh-2023-0012
22. Connellan SJ. Lung diseases associated with hydrocarbon exposure // Respir Med. 2017 May;126:46-51. https://doi.org/10.1016/j.rmed.2017.03.021
23. Sleptsova A. I., Bakirov A. B., Masyagutova L. M. Condition of the peripheric blood as the indicator of early disturbances of health at workers modern enterprises to getting and oil refining. current state of the question // Public Health and Life Environment – PH&LE. 2017;(11):25-29. (In Russ.) https://doi.org/10.35627/2219-5238/2017-296-11-25-28]
24. Timasheva G. V., Badamshina G. G., Gimranova G. G. Comparative estimation of biochemical indices of health state in workers of oil extraction and processing-r elated industries // Perm Medical Journal. 2010;27(5):138-142. (In Russ.)]
25. Schwartz JA, et al. Chronic fuel oil toxicity in American mink (Mustela vison): systemic and hematological effects of ingestion of a low-concentration of bunker C fuel oil. Schwartz JA, Aldridge BM, Lasley BL, Snyder PW, Stott JL, Mohr FC. // Toxicol Appl Pharmacol. 2004 Oct 15;200(2):146-58. https://doi.org/10.1016/j.taap.2004.04.004
26. Mohr FC, Lasley B, Bursian S. Fuel oil-induced adrenal hypertrophy in ranch mink (Mustela vison): effects of sex, fuel oil weathering, and response to adrenocorticotropic hormone. J Wildl Dis. 2010 Jan;46(1):103-10. https://doi.org/10.7589/0090-3558-46.1.103.
27. Schwartz JA, Aldridge BM, Stott JL, Mohr FC. Immunophenotypic and functional effects of bunker C fuel oil on the immune system of American mink (Mustela vison). // Vet Immunol Immunopathol. 2004 Oct;101(3-4):179-90. https://doi.org/10.1016/j.vetimm.2004.04.015
28. Szaro RC, Hensler G, Heinz GH.Effects of chronic ingestion of No. 2 fuel oil on mallard duckling // J Toxicol Environ Health. 1981 May;7(5):789-99. https://doi.org/10.1080/15287398109530020)
29. Gomes A, et al. Biodegradation of water- accommodated aromatic oil compounds in Arctic seawater at 0 оC. / Gomes A, Christensen JH, Gründger F, Kjeldsen KU, Rysgaard S, Vergeynst L. // Chemosphere. 2022 Jan;286(Pt 3):131751. https://doi.org/10.1016/j.chemosphere.2021.131751
30. Downs CA et al. Cellular physiological effects of the MV Kyowa violet fuel-oil spill on the hard coral, Porites lobate / Downs CA, Richmond RH, Mendiola WJ, Rougée L, Ostrander GK // Environ Toxicol Chem. 2006 Dec;25(12):3171-80. https://doi.org/10.1897/05-509r1.1.
31. Fiorello CV, et al. Ophthalmic effects of petroleum dispersant exposure on common murres (Uria aalge): An experimental study / Fiorello CV, Freeman K, Elias BA, Whitmer E, Ziccardi MH. //Mar Pollut Bull. 2016 Dec 15;113(1-2):387-391. https://doi.org/10.1016/j.marpolbul.2016.10.027
32. Abramochkin DV et al. Tricyclic hydrocarbon fluorene attenuates ventricular ionic currents and pressure development in the navaga cod. /Abramochkin DV, Filatova TS, Kuzmin VS, Voronkov YI, Kamkin A, Shiels HA. // Comp Biochem Physiol C Toxicol Pharmacol. 2023 Nov;273:109736. https://doi.org/10.1016/j.cbpc.2023.109736
33. Ouro-Sama K, et al. Polycyclic Aromatic Hydrocarbons (PAHs) Contamination in Chrysichthys nigrodigitatus Lacepede, 1803 from Lake Togo- Lagoon of Aneho, Togo: Possible Human Health Risk Suitable to Their Consumption / Ouro-Sama K, Tanouayi G, Solitoke HD, Barsan N, Mosnegutu E, Badassan TE, Agbere S, Adje K, Nedeff V, Gnandi K. // Int J Environ Res Public Health. 2023 Jan 17;20(3):1666. https://doi.org/10.3390/ijerph20031666
34. Ju Z, et al. Stranded heavy fuel oil exposure causes deformities, cardiac dysfunction, and oxidative stress in marine medaka Oryzias melastigma using an oiled- gravel-column system. / Ju Z, Li X, Li X, Liang C, Xu Z, Chen H, Xiong D. // Fish Physiol Biochem. 2025 Feb;51(1):29. https://doi.org/10.1007/s10695-024-01437-z
35. Santos RM, et al. Acute and subchronic effects of petroleum on the freshwater fish Hoplias aff. Malabaricus/ Santos RM, Petry AC, Sousa VL, Souza HO, Azevedo A, Soares AR, Weber LI. // Braz J Biol. 2022 Jan 7;84: e253731. https://doi.org/10.1590/1519-6984.253731. eCollection 2022
Review
For citations:
Evstafeva E.V., Kadochnikov D.S., Gritskevich O.Yu., Evstafeva I.A. On the issue of the consequences of oil and petroleum product spills for human health: a literary review. Issues of Risk Analysis. 2025;22(4):12–20. (In Russ.) EDN: CMHZJX